Antisickling Effect of Ficus vallis-choudae: A Potential Inhibitor of ErythrocyteMorphological Alterations in Sickle Cell Disease
DOI:
https://doi.org/10.37506/q4zmt370Keywords:
Sickle cell disease, Antisickling, Ficus vallis-choudaeAbstract
Background: The aim of this study is to evaluate whether a hydroethanolic extract of Ficus vallis-choudae (EFFV) leaves can
prevent the sickling of red blood cells in individuals with sickle cell carriers(AS) and homozygous sickle cells (SS).
Material and Methods: Ten grammes of Ficus vallis-choudae leaf powder were macerated in 100 ml of a 60% hydroethanolic
solution. After filtration, the macerate was subjected to rotary evaporation until a dry crude extract was obtained. This dry
extract was reconstituted in water to prepare two solutions with concentrations of 5 mg/ml and 2.5 mg/ml. Emmel tests
were performed following incubation of the extract solutions with blood from individuals with the AS sickle cell trait,
SS homozygous sickle cell disease, and normal AA controls. The percentage of sickled cells was determined using optical
microscopy.
Results: The hydroethanolic extract of Ficus vallis-choudae (EFFV) significantly reduces sickle cell formation in both AS and
SS individuals. This antisickling effect is dose-dependent.
Conclusion: Our results demonstrate that the hydroethanolic crude extract of Ficus vallis-choudae (EFFV) could have
beneficial effects in the context of sickle cell disease. These findings offer promising prospects for the development of
cost-effective treatments for this condition.
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Copyright (c) 2025 Mbaye SENE, Ibrahima Diouf, Awa BA, Diop Doudou, Niasse Rokhy, Ba Fatoumata, Diaw Ndeye Absatou, Kane Modou Oumy, Sarr Mamadou
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