Mechanism of Biological Aging-A Review
DOI:
https://doi.org/10.37506/ijop.v9i1.2607Keywords:
Hormesis, Senescence, Epigenetic, Endocrine dysfunction, IGF1 regulation.Abstract
Aging is a universal, inherent, natural phenomenon that occurs in all organism. Aging involves morphological
and functional changes in cellular and extracellular components leading to progressive decline in most
biological functions. It causes reduction in strength, basal metabolism, sexual activity and the body’s
defenses.
Aging is the progressive decline in the maintenance of homeostasis, which leads to decreased response of
the body against internal and external stress. It involves imbalance between free radicals and the antioxidant
mechanism lead to damaged cells, tissues, and organs resulting in age related changes.
With age there is modifications in energy metabolism, insulin sensitivity, neuroendocrine function and
induction of hormesis response. Telomere shortening, mitochondrial dysfunction, increase of oxidative
stress, alteration of insulin-like growth factor and growth hormone signaling are considered to be important
contributors of aging process.
Recently many genes and changes in gene expression have been found associated with aging which affects
many biological processes and are associated with senescence and oxidative stress.
This review focuses on the underlying mechanism of biological aging. With an increase in the number of
elderly population and the patients of age-related diseases, it is becoming increasingly important to consider
these in the field of research. We have attempted to discuss the different aging mechanism along with the
newer concepts, which can give a direction for the future research studies.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright Ownership: Authors retain copyright ownership of their work after publication in IJOP. However, they grant the journal an exclusive Creative Commons license.
Creative Commons License: The authors grant IJOP the right to exclusively apply a Creative Commons license to their work upon publication. This license permits use, distribution, and reproduction of the work in any medium, provided that the original work and its source are properly cited. The specific license applied is Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0), which allows for attribution, non-commercial use, and derivative works.
Editorial Research: Authors grant the journal the right to analyze information obtained from submitted manuscripts for editorial research purposes. This analysis aims to improve the peer-review process, teaching, and training activities.
Warranties: Authors warrant that their work is original, contains no libelous statements, is lawful, and does not infringe upon any copyright, trademark, patent, or proprietary rights of others. Authors agree to indemnify the editors against any costs, expenses, and damages arising from any breach of this warranty.
Views and Opinions: The views and opinions expressed in the article are those of the authors and not necessarily those of the journal.