Study of Lipid Profile and C- reactive Profile in Hypertensive Adult Patients of Andhra Pradesh

Abstract

95 adult (45 males and 50 females) aged between 30 and 75 having Hypertension and hyper lipidemia were studied. The mean value of CRP was 1.31 (SD+0.1.105), total cholesterol 259(SD+1.53) triglyceride 190.4 (SD+1.93) VLDL 32.2 (SD+1.8), HDL 34.3 (SD+1.5), LDL 165.3 (SD+2.10) systolic BP 145(SD+2.59), Diastolic BP 101.4 (SD+1.84) (mmHg). Correlation of CRP with lipid profile parameter were total cholesterol correlation coefficient value was -0.397 (p<0.01), triglyceride -0.562 (p<0.01), VLDL – 0.416 (p<0.01), HDL – 0.509 (P<0.01), LDL – 0.476 (p<0.01), systolic Bp – 0.409 (p<0.01), diastolic Bp – 0.420(p<0.01). The regression equation of CRP with lipid profile was CRP=9.91, total cholesterol – 0.00623, triglyceride - 0.0175, VLDL-0.0132, HDL – 0.02 35, LDL- 0.146. The regression equation of CRP with Blood pressure was CRP- 5.64, systolic BP=-0.0148, Diastolic BP- 0.0215. By knowing the value of CRP one can predict the values of lipid profile and vice versa It was revealed that increased CRP values strongly predict the future coronary events. These findings trigger widespread interest where the clinical use of CRP study had been largely ignored. CRP production is part of the nonspecific acute- phase response to most forms of inflammation, infection and tissue damage and was therefore considered not to provide clinically useful information. Indeed CRP values con never be diagnostic on their own and can only be interpreted at the bed side. The present study of CRP in cardio vascular disease and associated condition like hyper lipidemia have greater importance.