Serum Macrophage Migration Inhibitory Factor Levels in Patients with Ischemic Stroke in Iraqi Populations

Abstract

Background: Stroke is one of the leading causes of permanent disability worldwide. The most common
cause of stroke is the occlusion of blood circulation by a thrombus (or embolism) although it can also be
produced by the rupture of a vessel and subsequent bleeding in a certain region of the brain. Strokes can,
therefore, be classified as ischemic or hemorrhagic.
Aim: The present study was conducted to investigate whether serum MIF levels are associated with severity
in patients with ischemic stroke.
Method: A total of 40 patients with ischemic stroke were included in the study who were admitted to
hospital from the period between March to August 2019, and other groups consist of 40 apparently healthy
individuals. Two blood sample were taken from each patients one during attack (within 24 hours) and the
other sample during follow up (within 1-3 months) for serum concentration of MIF by ELISA technique.
Results: Mean serum concentration of MIF in Ischemic stroke during attack (within 24 hours) was
significantly higher than that of Ischemic stroke during follow up (within 1-3 months) and healthy control
group; 17.094±2.25ng/ml versus 12.83± 4.16ng/ml and 6.407± 3.33ng/ml respectively.