Synthesis of New Drug Carriers of Metronidazoleas Antifungal Agents

Abstract

New drug carriers were synthesised through etherification with sugar moiety and metronidazole drug. The
synthetic pathway was started with two sugars, ?-D-glucose and ?-D-fructose, which were protected as
peracetate and benzoate respectively, then converted to bromo sugar. The bromo sugars were subjected to
coupling with metronidazole drug via Willemenson reaction to afford protected drug carriers. All prepared
compounds were characterised via FT-IR, 1H-NMR and 13C-NMR and HR-MS spectroscopy. These new
carriers were tested against four types of fungi kandida yeast. Some of tested compounds showed moderate
activity while the other showed weak inhibition. Interestingly, two carrier drugs showed high activity against
fungi