Effect of Tamoxifen Drug on Testes of Albino Male Rats

Abstract

This study was conducted to evaluate the negative effects of Tamoxifen (TAM) on Testis tissues and
spermatogenesis. Use for this purpose forty male of mature albino rats were divided into 4 equal groups, 3
groups were administrated different doses (30, 40, 50) mg/kg b.w of TAM for 10 weeks as well as control
group administrated with physiological solution (normal saline 0.9%). Histopathological examination of
testes tissues in TAM groups showed histological changes that increased with the increased dose compared
to control group include degeneration change were appeared as atrophy, deformity and destruction of the
seminiferous tubules, congestion of blood vessels in the interstitial tissue and many seminiferous tubules,
Also the results showed a significant different in the numbers of spermatogonia, primary spermatocytes
cells and spermatiods. As noted in the results, the higher the dose, the lower the sperm production, and
consequently the tissue injury increases.