Correlation of Ki 67, Histopathological Features and Shape of  Lesion in Skeletally Mature Osteochondroma

Authors

Wafaa Redha Mohammed Al Sabbagh1 , Mushtaq Talib Hussein2 , Ali Fadhil Hashim3 , Enass Abdul Kareem Dagher Al-Saadi1

osteochondroma, proliferative marker, atypical histopathology, lesion shape, Ki 67 .

Background: Osteochondroma represents the most common benign tumor of bones and accounts for

about 30-50 % of them. poor information’s in previous studies act on demonstration of the significance

of atypical histological changes as a premalignant precursor in mature osteochondroma regardless of the

cap thickness. In this study, the proliferative activity of cartilaginous cap will be studied in skeletally

mature patients regardless of the cap thickness to demonstrate the independent significant of histological

features in predicting the malignant potential in osteochondroma. methodology : cases of skeletally mature

osteochondroma (78 case) were isolated and separated into sessile and pedunculated, then into G1(without

suspicious histological features) and G2 ( with suspicious features), and stained with Ki- 67 . Data were

analyzed using SPSS version 21and p value < 0.05 was considered as significant. Results: There was

significant association between study groups and Ki 67 staining results, majority (75%) of patients with

suspicious histopathological features presented with positive results of Ki 67 staining ( p value < 0.001).

while there was no correlation between shape of lesion and histopathological features ( p value 0.662).

Conclusion: atypical histopathological features can be regarded as independent factor with the other clinical

data when considering the diagnosis of grade 1 chondrosarcoma.