Histological and Enzyme Histochemical Changes of Liver  Induced By the Action of Maxxthor Insecticide in  Male Albino Rats

Authors

Entesar A. Essa1 , Sahar A.H. AL-Sharqi 2 , Jabbar H. Yenzeel3 , Layla J. Mohammed2

Maxxthor, Histopathology, Enzyme histochemical,liver function

The present study aimed to investigate the histological, enzyme histochemical changes and liver function

effects of Maxxthor insecticide on albino rats in liver. The experiment included 20 rat which were divided

into four groups, the first group 5 rats were considered the control animals and the others were divided

equally into three groups with a dose of 0.01, 0.1and 1 mg / kg of body weight, respectively for a period 40

days. The animals given each 48 hours via oral route Maxxthor by tube dosage after dissolved with distilled

water. Microscopic examination of liver showed inflammatory cell aggregation around vessels, congestion

and dilation of sinusoids hepatocytes hypertrophy with severs inflammatory cells infiltration, kupffer cells

proliferation and hydropic degeneration. Enzyme histochemical study of liver showed weak expression of

ALP activity in hepatocyte in low dose, sever expression in middle dose, and mild expression in high dose.

There was significantly increase in serum aminotransferases (ALT, AST) and alkaline phosphatase (ALP)

level in treated group of rats as compared with control group.

Entesar A. Essa1 , Sahar A.H. AL-Sharqi 2 , Jabbar H. Yenzeel3 , Layla J. Mohammed2

1 Post graduate, 2Assist Prof, Department of Biology, College of Sciences, Mustansiriyah University, Baghdad /

Iraq, 3Prof, Assist Prof, 3Department of Biology, College of Sciences, University of Baghdad, Baghdad /Iraq