Therapeutic Effect of Chemically Synthesized Silver Nanoparticles on Aphthous Stomatitis in Some Iraqi Patients

Abstract

Silver nanoparticles (AgNPs) were synthesized by a chemical reduction method. The particles were

synthesized using silver nitrate solution with sodium borohydride as the reducer. The resulting colloidal

AgNPs were characterized by UV-Visible spectroscopy, and FTIR. Aphthous stomatitis is a common and

recurrent painful disease of the oral mucous membrane, classified in to three different aphthous types: minor,

major and herpetiform. It may appear due to a variety of causes including: stress, food, hypersensitivities,

infection, trauma, drug allergy, nutrition deficiencies (Iron, zinc & vitamin B12) or it could be a symptom of

serious disease such as carcinoma. In this study, (75) young Iraqi patients aged (18-24) years divided in to

two groups according to their gender (25 male and 50 female) all of them are suffering from major Aphthous

ulcers in the mouth. The solution of (10 µg/ml) concentration of silver nanoparticles showed a uniform

cycle inhibition around the ulcer growth zone while, increasing of (AgNPs) solution to (20 µg/ml) showed

a highly and significant inhibitory effect against isolates from Aphthous stomatitis during the first 24 hours

only in both male and female groups. Further studies is needed to investigate the inhibitory mechanism of

(AgNPs) against Aphthous stomatitis.