Effects of Onion Extract on Hepar Histopatology in AlloxanInduced Diabetic Rattus Novergicus

Authors

Ni Komang Aprilina Widi Suputri1 , Ajik Azmijah2 , Retno Bijanti3 , Made Mahaguna Putra4

Allium ascalonicum, alloxan, liver, Rattus norvegicus.

This study was aimed to know the effect of giving shallot extract (Allium ascalonicum L) to histopathological

feature of rat (Rattus norvegicus) liver induced by alloxan. Alloxan was intraperitoneally injected 120 mg/

kg BW (single dose). A total of twenty male Wistar rats of three months old were used in the study. The rats

were divided into five groups. 1) negative control group (K-) treated by CMC Na 0.5 %, 2) positive control

group (K+) treated by metformin 45 mg/kg BW as a standard drug, 3) extract of Allium ascalonicum 250

mg/kg BW (P1), 4) extract of Allium ascalonicum 500 mg/kg BW (P2), 5) extract of Allium ascalonicum

750 mg/kg BW (P3). Rats were treated for 14 days. The data of this study were analyzed by Kruskal Wallis

Test, then it continued by Mann-Whitney Test. The result of this study is Allium ascalonicum can improve

the histopathological feature of rats liver induced by alloxan.