The Effect of Ethanoic Extract of Tetrapleuratetraptera (Uyayak) on Pain Sensitivity of Female Wistar Rats

Authors

  • Wami-Amadi, C. F
  • Owhorji B. I
  • Victor, P. D
  • Nonju, I. I
  • Edward, F. U
  • Oparaodu. U. A

DOI:

https://doi.org/10.37506/92mrpk86

Keywords:

Pain Sensitivity, Tetrapleura tetraptera, Hot plate test

Abstract

Background: In African traditional medicine, the dried pods of Tetrapleura tetraptera are frequently used to
manage different human ailments. In Nigeria, it is consumed in soups after childbirth to aid in wound healing,
pain relief, uterine recovery, and lactation. The study investigates the impact of Tetrapleura tetraptera fruit extract
on pain sensitivity using Wistar rats.
Methods: Twelve female Wistar rats were divided into two groups (Group 1 - Control and Group 2 -100mg/
kg Tetrapleura tetraptera extract-fed) and received standard rat chow and water for fourteen days following
which pain sensitivity was assessed using a hot plate. The results were presented as Mean and Independent
Student T-test was utilized for statistical analysis with significance determined at P≤0.05. Increased pain tolerance
indicated reduced sensitivity.
The escape latencies of both groups were 5secs and 10secs respectively. Group 2 demonstrated a noteworthy
increase in pain tolerance compared to Group 1 (P < 0.05). analgesic This experimental study indicates that the
ethanoic extract of Tetrapleura tetraptera fruit has properties.
Conclusion: The result of this study provides support for the use of dried Tetrapleura tetraptera pods in pain
management across some communities in Southern Nigeria.

Author Biographies

  • Wami-Amadi, C. F

    Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Rivers
    State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria,

  • Owhorji B. I

    Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Rivers
    State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria,

  • Victor, P. D

    Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria,

  • Nonju, I. I

    Department of Human Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, Rivers
    State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria,

  • Edward, F. U

    Department of Pharmacology, Faculty of Basic Clinical Sciences, College of Medical Sciences, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria

  • Oparaodu. U. A

    Department of Otorhinolaryngology, Faculty of Clinical Sciences, College of Medical Sciences, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Nigeria.

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Published

2024-01-23

Issue

Vol. 12 No. 1 (2024): International Journal of Physiology

Section

Articles

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How to Cite

The Effect of Ethanoic Extract of Tetrapleuratetraptera (Uyayak) on Pain Sensitivity of Female Wistar Rats. (2024). International Journal of Physiology, 12(1), 36-39. https://doi.org/10.37506/92mrpk86