A Study of Lipid Profile in Obese Hypertensive Subjects

Abstract

Background: Obesity is a significant risk factor for metabolic syndrome in adults. Central fat distribution
greatly alters the lipid profile and induces atherogenic dyslipidemia even in normoglycaemic, nonhypertensive
subjects.
Aim and Objectives: Hence, the aim of the present study to assess lipid profile changes in non-obese
hypertensive subjects. Obesity, hypertension and dyslipidemia are the three highly significant risk factor
for the deranged lipid profile. Obesity can be defined as excess accumulation of body fat arising from
a sustained or a periodic positive energy balance that when energy intake exceeds energy expenditure1.
Indicators of overweight are useful in the diagnosis and management of obesity in both children and adults.
Material & Methods: This study was conducted on newly diagnosed cases of essential hypertension
attending medical outdoor of M.G.M. Medical College, Kisangani. A complete clinical examination
including laboratory investigation was done to exclude any systemic or other diseases which are likely to
affect blood lipid levels directly or indirectly.
Results- The association between dyslipidaemia, obesity and hypertension is well establishedand all have
been found to be major risk factor for the development of CAD, a leading cause of visits to physician and
cause of death .
Conclusion: Our study was envisaged to know the effect of obesity on lipid profile profile only in
hypertensive and not in general population, and the study found some definite but paradoxical effects.
These are that in obesity on a background of hypertension, the total and LDL cholesterol as also the HDL
cholesterol are decreased, but on use other hand, the value of VLDL cholesterol and triglycerides are grossly
and significantly increased. These finding have two major Clinical implications in that obese hypertensives
will be more prone to metabolic syndrome and type 2 diabetes mellitus, and steps should be taken to prevent
them accordingly and also apart from statins one should treat the obese hypertensives with fibrates, fat
restriction and physical exercise also.