Major Depression Induced Endocrine Modulation is a Risk Factor for Low bone Mineral Density in Premenopausal Women
DOI:
https://doi.org/10.37506/ijop.v9i1.2608Keywords:
BMD, Cortisol, Depression, Premenopausal women, Vitamin D, secondary osteoporosis.Abstract
Background: The significant physiological effects of psychological depression are beginning to be
recognized as exacerbating common diseases, including osteoporosis. This review discusses the current
evidence for psychological depression-associated mental health disorders as risk factors for osteoporosis,
the mechanisms that may link these conditions, and potential implications for treatment
Osteoporosis is a major public health threat and depression is second most important cause of disability
worldwide in 2020. Several studies have reported an association between depression and low bone mineral
density, but a causal link between these two conditions is disputed.We propose that depression induces early
bone loss in premenopausal women, primarily via specific endocrine mechanisms associated poor lifestyle
habits contributory.
Aim and Objectives: To find the clinical correlation between depression, serum cortisol, vitamin D,
hypothyroidism and BMD in Premenopausal Women.
To find out a new risk factor of secondary osteoporosis in premenopausal women.
Methods: The study group consisted of 80 osteoporotic female patient’s age range between 30-60years.The
state of depression was analyzed by using Ham D scale. BMD and endocrine parameters was measured by
DEXA and chemiluminisence,ELISA. Statistical correlation analyzed by SPSS22software.
Results: A highly significant (P <0.00001) correlation was observedbetween HAM-D score and serum
cortisol. The correlation between HAM-D and BMD was also significant (P <0.05).No significant correlation
was found between BMD and serum cortisol (P? 0.05).The correlation of serum vitamin D with BMD was
far more significant (P<0.00001) compared to the association with TSH (P<0.0001).
Discussion & Conclusion: A high score of depression associated with low vitamin D level or high serum
cortisol and TSH level which is a risk factor for low BMD in premenopausal women to develop secondary
osteoporosis
It can be concluded that Irrespective of the specific causes, subjects with depression should be considered
for screening for bone mineral density and, vice versa, subjects with low BMD should be considered for
screening for depression in early stage of life and supplementation of vitamin D with regular physical
activity in premenopausal women for prevention of secondary osteoporosis.
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright Ownership: Authors retain copyright ownership of their work after publication in IJOP. However, they grant the journal an exclusive Creative Commons license.
Creative Commons License: The authors grant IJOP the right to exclusively apply a Creative Commons license to their work upon publication. This license permits use, distribution, and reproduction of the work in any medium, provided that the original work and its source are properly cited. The specific license applied is Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0), which allows for attribution, non-commercial use, and derivative works.
Editorial Research: Authors grant the journal the right to analyze information obtained from submitted manuscripts for editorial research purposes. This analysis aims to improve the peer-review process, teaching, and training activities.
Warranties: Authors warrant that their work is original, contains no libelous statements, is lawful, and does not infringe upon any copyright, trademark, patent, or proprietary rights of others. Authors agree to indemnify the editors against any costs, expenses, and damages arising from any breach of this warranty.
Views and Opinions: The views and opinions expressed in the article are those of the authors and not necessarily those of the journal.