Study of Variations in Heart Rate., QT and QTc During Different Phases of Menstrual Cycle
DOI:
https://doi.org/10.37506/ijop.v8i2.1242Keywords:
ECG, QTc, Menstrual cycle, influence of estrogenAbstract
Aim: The present study was undertaken with the aim to investigate influence of hormonal fluctuation during
menstrual cycle on ECG.
Materials and Method: The present study was carried out on 30 healthy female medical students in the
age group of 18 to 23 years with normal menstrual cycle of 27-33 days. ECG was recorded on 2nd,11th,22nd
day of menstrual cycle (corresponding with menstrual phase, proliferative phase and secretory phase of
menstrual cycle), using AD INSTRUMENT–POWERLAB®/30 Series.
Results: The study revealed that Heart rate was significantly (P<0.05) increased in secretory phase
(98.26±10.44) compared to menstrual phase (91.85±10.27).QT and QTc interval showed increase during
proliferative phase but not significant.
Discussion: Fluctuation in both estrogen and progesterone during menstrual cycle influence not only phase-
II of cardiac action potential but also autonomic tone which could have led to prolonged QTc in Proliferative
phase and increase in heart rate during secretory phase in present study, which provides a screening tool
to avoid morbidity due to intake of drugs which prolonged QTc interval during menstrual cycle. But QTc
interval in present study was not increased significantly as it was done during single cycle.
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