Recent advances in transplant medicine: Fertility restoration and redefining parentage in uterine and ovarian transplantation

Abstract

Background *
Around the globe the factors like female reproductive system disorders, cancer therapies, genetic associated syndromes often lead to around 35-37% of female infertility. The infertility due to absolute uterine and ovarian factors remains a challenging condition despite the availability of many treatment options. The ovarian autografts for restoring the hormonal function and fertility in cancer survivors, ovarian allografts from the donors, and uterine transplantation offer a huge potential in restoring fertility in women. Therefore, this study helps to know about the role of uterine and ovarian transplantation in restoring menstrual function and for treating infertility and about the issues in parentage

Methods *
A systematic review study and a descriptive meta-analysis were conducted on 16 studies. These studies included 130 cases of ovarian autografts, 4 cases of ovarian allograft, and 3 uterine transplantation cases. The Outcomes were assessed and a Statistical analysis was made, and the comparing groups were performed with p-values and when appropriate we calculated that around 95% confidence intervals were considered.

Results *
It is seen that the live birth rates and menstrual function restoration is 100% in uterine transplants and ovarian allografts. In ovarian autografts about 64% showed menstrual function restoration and the live birth rates were about 66%.

Conclusion *
This study concludes that the type of transplantation procedure mainly determines the genetic origin and reproductive success of the offspring. The uterine and ovarian transplantation procedures ensure a promising future in treating the infertility in women.