The Phytochemical and Pharmacological Profile of Capalobia lutea: Implications for Male Reproductive Health
DOI:
https://doi.org/10.37506/wczde796Keywords:
Capalobia lutea, phytochemicals, traditional medicine, infertility, spermatogenesis.Abstract
Capalobia lutea, a medicinal plant renowned in traditional African medicine, has gained interest for its potential therapeutic applications in male reproductive health. Traditionally used for treating various ailments, including reproductive disorders, C. lutea is rich in bioactive phytochemicals that may offer a natural alternative for addressing infertility and other reproductive health challenges. This review aims to consolidate current knowledge on the phytochemical profile of C. lutea, emphasizing its pharmacological actions relevant to male reproductive health. Key phytochemicals, such as flavonoids, alkaloids, and terpenoids, exhibit significant antioxidant, anti-inflammatory, and hormonal regulatory properties that are hypothesized to support male fertility by enhancing spermatogenesis, mitigating oxidative stress, and modulating testosterone levels. This article also examines the mechanisms underlying these
effects, comparing them to other medicinal plants used in reproductive health, and discusses the safety profile and toxicological considerations for C. lutea. By elucidating the phytochemical composition and pharmacological actions of C. lutea, this review highlights its potential role in developing new phytotherapeutic agents for managing male reproductive health issues and outlines
avenues for further pharmacological and clinical research.
References
1. A Burkill HM. Useful Plants of Ghana: West African
Uses of Wild and Cultivated Plants. London:
Intermediate Technology Publications and the Royal
Botanic Gardens, Kew; 1990.
2. Agarwal A, Mulgund A, Hamada A, Chyatte MR.
A unique view on male infertility around the globe.
Reprod Biol Endocrinol. 2015;13(1):37. doi:10.1186/
s12958-015-0032-1
3. Aitken RJ, Baker MA. Oxidative stress, spermatozoa,
and leukocytic infiltration: Relationships forged by the
opposing forces of microbial invasion and the search
for perfection. J Reprod Immunol. 2020;142:103217.
doi:10.1016/j.jri.2020.103217
4. Akintunde WO, Abdulfatai A, Adeleke MT. Effect
of aqueous extract of Carpolobia lutea stem on some
reproductive parameters in adult male Wistar rats.
J Med Plants Res. 2020;14(10):479-485.
5. Aravind G, Debjit B, Duraivel S, Harish G. Traditional
and medicinal uses of Cucumis sativus. J Pharmacogn
Phytochem. 2013;2(1):139-141.
6. Cushnie TP, Cushnie B, Lamb AJ. Alkaloids:
An overview of their antibacterial, antibioticenhancing
and antivirulence activities. Int J
Antimicrob Agents. 2014;44(5):377-386. doi:10.1016/j.
ijantimicag.2014.06.001
7. Dalziel JM. The Useful Plants of West Tropical Africa.
London: Crown Agents for Overseas Governments
and Administrations; 1937.
8. Dhawan D, Gupta J. Comparison of different solvents
for phytochemical extraction potential from Datura
metel plant leaves. Int J Biol Chem. 2011;5(2):75-81.
doi:10.3923/ijbc.2011.75.81
9. Ekor M. The growing use of herbal medicines:
Issues relating to adverse reactions and challenges
in monitoring safety. Front Pharmacol. 2014;4:177.
doi:10.3389/fphar.2013.00177
10. Emeka PM, Obidoa O. Effect of diet on blood glucose,
body weight and lipid profile in streptozotocininduced
diabetic rats treated with single and
combinatory doses of extracts of Vernonia amygdalina
and Azadirachta indica. J Ethnopharmacol.
2009;123(2):292-299. doi:10.1016/j.jep.2009.02.039
11. Gupta S, Kachhawa JBS, Singh M. Pharmacological
and therapeutic potential of Withania somnifera
(Ashwagandha): A review. Int J Pharm
Sci Res. 2016;7(7):2633-2641. doi:10.13040/
IJPSR.0975-8232.7(7).2633-41
12. Hutchinson J, Dalziel JM. Flora of West Tropical
Africa. Vol. 1, Part 2. London: Crown Agents for
Overseas Governments and Administrations; 1954.
13. Ijeh II, Nwogu LA, Obidoa O. Phytochemical
constituents and effects of extracts of Carpolobia
lutea on the testicular integrity of rats. Phytother Res.
2004;18(8):669-674. doi:10.1002/ptr.1528
14. Irvine FR. Woody Plants of Ghana. London: Oxford
University Press; 1961.
15. Jamal A, Javed K, Aslam M, Jafri MA. Gastroprotective
effect of cardamom (Elettaria cardamomum Maton)
seeds: A traditional remedy against gastric disorders.
J Ethnopharmacol. 2016;Available from: verify
completion details
16. Jensen TK, Priskorn L, Holmboe SA, Andersson
AM. Temporal trends in semen quality and the
impact on male reproductive health. Nat Rev Urol.
2017;14(9):551-564. doi:10.1038/nrurol.2017.115
17. Khan A, Safdar M, Ali Khan MM, Khattak KN,
Anderson RA. Cinnamon improves glucose and
lipids of people with type 2 diabetes. Diabetes Care.
2003;26(12):3215-3218. doi:10.2337/diacare.26.12.3215
18. Komakech R, Omujal F, Tushabe J, Kyakulaga A.
Medicinal plants used in managing male reproductive
health disorders: A systematic review. Afr J Reprod
Health. 2019;23(4):104-121. doi:10.29063/ajrh2019/
v23i4.11
19. Kumar S, Rani A, Choudhary M, Sharma S, Sharma
N. Review on medicinal and pharmacological
properties of Tribulus terrestris Linn. J Pharm Sci Res.
2015;7(9):253-259.
20. Mahmoud AM, Abd El-Twab SM, Abdel-Reheim
ES, Mohammed HS. Dietary supplementation of
pomegranate extract alleviates di-(2-ethylhexyl)
phthalate-induced testicular toxicity in male rats.
Chem Biol Interact. 2019;307:85-93. doi:10.1016/j.
cbi.2019.04.011
21. Mahmoud AM, Hernández Bautista RJ, Sandhu MA,
Hussein OE. Beneficial effects of citrus flavonoids on
cardiovascular and metabolic health. Oxid Med Cell
Longev. 2019;2019:5484138. doi:10.1155/2019/5484138
22. Nwafor SV. Pharmacological studies on Carpolobia
lutea extracts in animal models. Afr J Pharm
Pharmacol. 2010;4(10):695-701.
23. Okoli RI, Aigbe O, Ohaju-Obodo JO, Mensah JK.
Medicinal herbs used for managing some common
ailments among Esan people of Edo State, Nigeria.
Pak J Nutr. 2010;9(8):751-756.
24. Rogers JM, Kavlock RJ, Chapin RE. Male reproductive
toxicology. Environ Health Perspect. 2013;101:7-17.
25. Shalaby MA, El-Refaiy AI, Mahmoud MM, Khalaf AA.
The protective effect of omega-3 against cadmiuminduced
testicular damage and apoptosis in rats:
Role of oxidative stress, inflammation, and apoptotic
pathway. Environ Sci Pollut Res. 2021;28(10):12316-
12328.
26. Sharma R, Biedenharn KR, Fedor JM, Agarwal A.
Lifestyle factors and reproductive health: Taking
control of your fertility. Reprod Biol Endocrinol.
2018;16(1):26. doi:10.1186/s12958-018-0334-4
27. World Health Organization. Global prevalence and
burden of infertility. Geneva: WHO; 2016.
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